Gestational diabetes & diabetes in pregnancy
Lifetime history of gestational diabetes and cognitive function in parous women in midlife
Authors' conclusion
Women with a history of GDM had poorer cognition than those without GDM. If replicated, our findings support future research on early risk modification strategies for women with a history of GDM as a potential avenue to decrease their risk of cognitive impairment.
Study context
- Population
- Parous women (≥1 birth at ≥18 years) who completed a cognitive assessment, free of CVD, cancer and diabetes before first birth; mean age 62.0 years (SD 4.9) at assessment
- Participants
- 15,906 women
- Comparison
- History of gestational diabetes mellitus (GDM) vs no history of GDM
- GDMn = 749
- Primary endpoint
- Composite z scores for psychomotor speed/attention, learning/working memory and global cognition (Cogstate brief battery)
Methodological detailscognition sub-study (2 waves), mediation analysis by T2D
- Cognition sub-study (2 waves)
- Mediation analysis by T2D
Primary result
As reported in the abstract
Cognitive function (composite z scores)
Β (psychomotor speed/attention)
−0.08
95% CI −0.14 to −0.01
GDM
Β (global cognition)
−0.06
95% CI −0.11 to −0.01
GDM
Original publication
Lifetime history of gestational diabetes and cognitive function in parous women in midlife. Diabetologia. Published 6 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →