Gestational diabetes & diabetes in pregnancy
Gestational diabetes and risk of type 2 diabetes: exploring the role of the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors' conclusion
A history of GDM is associated with an unfavourable gut microbiota and related metabolites in US Hispanic/Latino women, suggesting a potential role of the gut microbiota in GDM-related type 2 diabetes.
Study context
- Population
- US Hispanic/Latino parous women, HCHS/SOL; median age 58 yearsmicrobiome analysis, visit 2
- Participants
- 1,525 women
- Exposure
- History of gestational diabetes mellitus (GDM) vs no history of GDM
- Outcome
- Gut microbial species associated with a history of GDM
Methodological detailsmultiomic analysis of gut microbiome and serum metabolites, proxy analysis, mediation analysis
- Multiomic analysis of gut microbiome and serum metabolites
- Proxy analysis
- Mediation analysis
Main finding
As reported in the abstract
Species differing between women with and without a history of GDM
7
Species with higher abundance with GDM history (e.g. Parabacteroides merdae CAG:48, proinflammatory taxon)
4
Species with lower abundance with GDM history (e.g. Dialister sp. CAG:588, short-chain fatty acid producer)
3
Observational data: associations, not effects.
Further findings
Serum metabolites associated with both GDM history and GDM-related microbiome
- Metabolites associated with both, in a consistent direction
- 15
- Of these, associated with glycaemic traits and incident T2D (e.g. saturated sphingomyelins, unsaturated fatty acids)
- 9
Proxy analysis: GDM-related microbiome and T2D
- Positive relationship between GDM-related microbiome and T2D, r
- 0.55, p=0.036
Mediation of GDM history–T2D association by metabolite score of 9 microbial-related metabolites
- Estimated proportion mediated
- 20% (95% CI 9%, 42%)
Original publication
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