Gestational diabetes & diabetes in pregnancy
Gut microbiome and serum metabolic alterations in recurrent gestational diabetes mellitus
Authors' conclusion
These findings highlight potential interventions for preventing GDM through modulation of gut microbiota and metabolic byproducts during pregnancy.
Study context
- Population
- Pregnant women with prior gestational diabetes mellitus (GDM), Beijing, China; fecal and serum samples in first (8–12 weeks) and second trimesters (24–28 weeks)
- Participants
- 70 women
- Outcome
- Gut microbiome and serum metabolic alterations in recurrent GDM
Methodological details16S rRNA sequencing, untargeted metabolomics, Mendelian randomization analyses
- 16S rRNA sequencing
- Untargeted metabolomics
- Mendelian randomization analyses
Main finding
As reported in the abstract
- Recurrent GDM: stage-specific microbial dysbiosis, with early enrichment of pro-inflammatory taxa (e.g., Streptococcus, Enterobacter) and depletion of beneficial Bacteroidales, then mid-pregnancy loss of Lactobacillaceae and Desulfovibrio
- Reduced microbial community cohesion in recurrent GDM (network analysis)
- Downregulation of caffeine metabolites and lipids in recurrent GDM
Observational data: associations, not effects.
Further findings
Mendelian randomization (MR) analyses (Finnish, Canadian and UK Biobank cohorts)
- Taxa that may influence GDM risk, mediated by metabolites such as lipid signaling
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Original publication
Gut microbiome and serum metabolic alterations in recurrent gestational diabetes mellitus. Diabetes Res Clin Pract. Published 11 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →