Gestational diabetes & diabetes in pregnancy
Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome
Authors' conclusion
Adverse pregnancy outcomes in women with type 1 diabetes are reflected by distinct changes in the vaginal microbiome. This highlights the importance of monitoring and managing the vaginal microbiome in high-risk pregnancies, particularly those complicated by type 1 diabetes. Early detection and treatment of risk-associated taxa, e.g. G. vaginalis in the case of PE, could potentially improve vaginal health and pregnancy outcomes in women with type 1 diabetes.
Study context
- Population
- Pregnant women with and without T1D, third trimesterbacteria
- Participants
- 310 pregnancies
- Exposure
- Pregnant women with vs without T1D; Pre-term birth (PTB) and pre-eclampsia (PE) within T1D
- T1Dn = 160
- Outcome
- Vaginal microbiome in T1D vs without T1D
- Follow-up
- Third trimester
Methodological details16S rRNA gene sequencing, internal transcribed spacer 1 sequencing, third trimester sampling
- 16S rRNA gene sequencing
- Internal transcribed spacer 1 sequencing
- Third trimester sampling
Main finding
As reported in the abstract
- Increased Lactobacillus iners and Lactobacillus jensenii, and anaerobic genera Gardnerella, Anaerococcus, Prevotella, Dialister, Peptoniphilus and others associated with vaginal dysbiosis, in T1D
- Increased abundance of fungal species Malassezia restricta in T1D
- These changes were associated with increased risks of PTB and PE
Observational data: associations, not effects.
Further findings
Pre-term birth (PTB) in T1D
- PTB associated with higher bacterial alpha diversity, decreased Lactobacillus reuteri, and increased Malassezia genus, family Malasseziaceae and order Malasseziales
Pre-eclampsia (PE) in T1D
- PE associated with higher bacterial alpha diversity, increased Gardnerella vaginalis and decreased Candida albicans
Original publication
Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome. Diabetologia. Published 7 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →