Gestational diabetes & diabetes in pregnancy
Low prolactin levels as a marker of gestational diabetes in late pregnancy
Authors' conclusion
Lower third-trimester prolactin levels are independently associated with GDM and may serve as a hormonal marker of impaired metabolic adaptation. Serial prolactin profiling could aid in endocrine-based risk stratification.
Study context
- Population
- Pregnant women followed throughout gestation; GDM diagnosed by 75-g OGTT
- Participants
- 120 women
- Exposure
- GDM vs non-GDM
- GDMn = 67
- non-GDMn = 53reference
- Outcome
- Independent association between third-trimester prolactin and GDM
- Follow-up
- Third trimester
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
Third-trimester prolactin and GDM
- Prolactin threshold < 182 μg/L for identifying GDM: sensitivity
- 59.5 %
- Specificity
- 90 %
- AUC
- 0.72 ± 0.087,p = 0.009
- Logistic regression confirmed association
- p = 0.034
Observational data: associations, not effects.
Further findings
Correlations of prolactin with glycaemic measures
- First-trimester prolactin inversely correlated with fasting glucose
- r = −0.4; p = 0.02
- Second-trimester prolactin inversely correlated with mid-gestation HbA1c
- r = −0.5; p = 0.035
- Second-trimester prolactin inversely correlated with late-gestation HbA1c
- r = −0.9; p < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Low prolactin levels as a marker of gestational diabetes in late pregnancy. Diabetes Res Clin Pract. Published 3 August 2025. doi:10.
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