Gestational diabetes & diabetes in pregnancy
Continuous Glucose Monitoring Prediction of Gestational Diabetes Mellitus and Perinatal Complications
Authors' conclusion
CGM-measured hyperglycemic metrics such as TA140 predicted GDM with high AUROCs as early as 13-14 weeks of gestation. These metrics were also similar statistically to the OGTT at 24-34 weeks in predicting perinatal complications, although sensitivity was low for both.
Study context
- Population
- Pregnant females with continuous glucose monitoring (CGM) data collected throughout gestation after enrollment
- Participants
- 760 females
- Exposure
- CGM-measured glycemic metrics vs oral glucose tolerance test (OGTT) for predicting gestational diabetes mellitus (GDM) and perinatal complications
- Outcome
- Prediction of GDM (diagnosed by OGTT at 24-34 weeks), assessed by AUROC
Methodological detailsdiagnostic prediction modelling (logistic and elastic net regression)
- Diagnostic prediction modelling (logistic and elastic net regression)
Main finding
As reported in the abstract
Prediction of GDM
| Group | Area under the receiver-operating characteristic (AUROC) |
|---|---|
| Second trimester TA140 | 0.81 |
| Week 13-14 TA140 | 0.74 |
Area under the receiver-operating characteristic (AUROC)
Second trimester TA1400.81
Week 13-14 TA1400.74
Observational data: associations, not effects.
Further findings
| Outcome | Second trimester TA140 | Week 13-14 TA140 | OGTT |
|---|---|---|---|
| Prediction of LGA births and HDP | |||
| AUROC (LGA) | 0.58 | — not stated in the abstract | — not stated in the abstract |
| AUROC (HDP) | 0.58 | — not stated in the abstract | — not stated in the abstract |
| Sensitivity for HDP and LGA at OGTT-matched specificity | |||
| Sensitivity (HDP) | — not stated in the abstract | 13% | 10% |
| Sensitivity (LGA) | — not stated in the abstract | 6% | 6% |
— not stated in the abstract
Sensitivity for hypertensive disorders of pregnancy (HDP) and large-for-gestational-age (LGA) at OGTT-matched specificity
- Similar sensitivity of TA140 model and OGTT
Elastic net models
- Similar AUROC and diagnostic performance; no meaningful improvement with multiple predictors
Original publication
Continuous Glucose Monitoring Prediction of Gestational Diabetes Mellitus and Perinatal Complications. Diabetes Technol Ther. Published 23 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →