Gestational diabetes & diabetes in pregnancy
Continuous Glucose Monitoring Profiles in Pregnancies With and Without Gestational Diabetes Mellitus
Authors' conclusion
Prior to OGTT at 24-34 weeks' gestation, pregnant individuals who develop GDM have higher CGM-measured glucose levels and more hyperglycemia compared with those who do not develop GDM.
Study context
- Population
- Pregnant individuals enrolled before 17 weeks' gestation at two sites, June 2020–December 2021, wearing blinded Dexcom G6 continuous glucose monitoring (CGMs) throughout gestation
- Participants
- 768 individuals
- Exposure
- Gestational diabetes mellitus (GDM) vs no GDM
- GDMn = 58
- Outcome
- Diagnosis of GDM by OGTT
Methodological detailstwo sites, blinded CGM
- Two sites
- Blinded CGM
Main finding
As reported in the abstract
CGM metrics throughout gestation prior to OGTT
Glucose SD GDM 23 ± 4 mg/dL · Without GDM 19 ± 3 mg/dL
Time in range 63-120 mg/dL GDM 70% ± 17% · Without GDM 84% ± 8%
Median % time >120 mg/dL GDM 23% · Without GDM 12%
Median % time >140 mg/dL GDM 7.4% · Without GDM 2.7%
- GDM vs Without GDM: P < 0.001 — higher with GDM
- GDM vs Without GDM: P < 0.001 — greater with GDM
- GDM vs Without GDM: P < 0.001 — less with GDM
- GDM vs Without GDM: P < 0.001 — greater with GDM
- GDM vs Without GDM: P < 0.001 — greater with GDM
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Median % time >120 mg/dL (>6.7 mmol/L) · 13-14 weeks of gestationHigher with GDM | P < 0.001 |
| Median % time >140 mg/dL (>7.8 mmol/L) · 13-14 weeks of gestationHigher with GDM | P < 0.001 |
Median % time >120 mg/dL (>6.7 mmol/L) · 13-14 weeks of gestation
- Higher as early as 13-14 weeks and persisted during the entire study period prior to oral glucose tolerance test (OGTT)
Median % time >140 mg/dL (>7.8 mmol/L) · 13-14 weeks of gestation
- Higher as early as 13-14 weeks and persisted during the entire study period prior to OGTT
Original publication
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