Gestational diabetes & diabetes in pregnancy
Incident Diabetes in Women With Patterns of Gestational Diabetes Occurrences Across 2 Pregnancies
Authors' conclusion
In this retrospective cohort study of nearly half a million women with 2 singleton pregnancies, both the number and ordinal pregnancy of any gestational diabetes occurrence increased diabetes risk. These considerations offer greater nuance than an ever or never gestational diabetes dichotomy.
Study context
- Population
- Mothers with 2 singleton deliveries (1990–2012) without diabetes before or between pregnancies, Quebec, Canada; mean age 30.1 years at second delivery12,205 diabetes events
- Participants
- 431,980 mothers
- Exposure
- GDM in first pregnancy only, second pregnancy only, or both vs no GDM in either pregnancy
- First pregnancy-only GDMn = 10,920
- Second pregnancy-only GDMn = 16,145
- GDM in both pregnanciesn = 8,255
- Outcome
- Incident diabetes from the second delivery until a third pregnancy, death or end of follow-up
- Follow-up
- Median 11.5 years (IQR 5.3-19.4)
Methodological detailspopulation-based administrative databases
- Population-based administrative databases
Main finding
As reported in the abstract
Incident diabetes
Each group vs no GDMHazard ratio (95% CI)
First pregnancy-only GDMhazards increased 4.35-fold
4.35(4.06–4.67)
Second pregnancy-only GDMhazards increased 7.68-fold
7.68(7.31–8.07)
GDM in both pregnancieshazards increased 15.8-fold
15.8(15.0–16.6)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident diabetes vs first pregnancy-only GDMGDM in both pregnanciesvs First pregnancy-only GDMHazards increased 3.63-fold | 3.63 (3.36–3.93) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Estimate |
|---|---|
| Incident diabetes vs first pregnancy-only GDMSecond pregnancy-only GDM vs First pregnancy-only GDM · hazards increased by 76% | (95% CI 1.63–1.91) |
Original publication
Incident Diabetes in Women With Patterns of Gestational Diabetes Occurrences Across 2 Pregnancies. JAMA Netw Open. Published 1 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →