Gestational diabetes & diabetes in pregnancy
Basal Hyperglycemia Contributes More Than 50% to Time in Range in Pregnant Women With Type 1 Diabetes
Authors' conclusion
Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling PHG, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.
Study context
- Population
- Pregnant women with T1D from the CARNATION study wearing continuous glucose monitoring (CGM) during pregnancy; mean age 28.8 ± 3.9 years, diabetes duration 8.4 ± 6.2 years
- Participants
- 112 pregnancies
- Exposure
- Basal hyperglycemia (BHG) vs postprandial hyperglycemia (PHG) contribution across time in range (TIR) categories
- Outcome
- Relative contribution of BHG and PHG to TIR categories and adverse pregnancy outcomes
- Follow-up
- During pregnancy
Main finding
As reported in the abstract
BHG contribution rate
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | TIR<60% | TIR 60%-78% | TIR ≥78% | P value |
|---|---|---|---|---|
| PHG contribution rateBetween TIR<60% and TIR ≥78% · across TIR<60%, 60%-78%, ≥78% | 25.1% (range 0–63.2) | 30.8% (range 0–86.6) | 33.5% (range 0–90.0) | P < 0.001 |
Glycaemia during pregnancy (all women)
- Mean TIR
- 75.6 ± 19.0%
- Mean HbA1c
- 6.2 ± 1.1%
Adverse pregnancy outcomes
- Higher BHG contribution rates tended to have more adverse pregnancy outcomes
Original publication
Basal Hyperglycemia Contributes More Than 50% to Time in Range in Pregnant Women With Type 1 Diabetes. J Clin Endocrinol Metab. Published 30 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →