Gestational diabetes & diabetes in pregnancy
One-Hour Oral Glucose Tolerance Test for the Postpartum Reclassification of Women With Hyperglycemia in Pregnancy
Authors' conclusion
The 1-h OGTT may offer a strategy for increasing rates of postpartum reclassification following hyperglycemia in pregnancy.
Study context
- Population
- Women across a range of glucose tolerance in pregnancy (normoglycemia to GDM)
- Participants
- 369 women
- Exposure
- 1-h vs 2-h oral glucose tolerance test (OGTT) glucose at 3 months postpartum as predictors of dysglycemia
- Outcome
- Dysglycemia (prediabetes/diabetes), predictors ranked by change in concordance index (CCI) of Cox models
- Follow-up
- Over the first 5 years postpartum
Methodological detailsserial OGTTs at 3 months, 1 year, 3 years and 5 years postpartum
- Serial OGTTs at 3 months, 1 year, 3 years and 5 years postpartum
Main finding
As reported in the abstract
Prediction of dysglycemia (change in CCI) · 5 years postpartum
1-h glucose
16.1%
2-h glucose
14.9%
Observational data: associations, not effects.
Further findings
| Outcome | 1-h glucose | 2-h glucose |
|---|---|---|
| Prediction of dysglycemia in women with GDM (change in CCI) | 13.0% | 12.8% |
Concurrent dysglycemia diagnosis at 3-month OGTT · 3 months postpartum
- Women diagnosed with dysglycemia by 2-h glucose
- 70
- Of these, not identified by 1-h glucose
- 10
- Additional women diagnosed by 1-h glucose
- 96
Cumulative incidence of dysglycemia by tertile of 1-h glucose · over 5 years
- Cumulative incidence progressively increased by tertile of 1-h glucose
- P < 0.0001
Original publication
One-Hour Oral Glucose Tolerance Test for the Postpartum Reclassification of Women With Hyperglycemia in Pregnancy. Diabetes Care. Published 3 March 2025. doi:10.
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