Gestational diabetes & diabetes in pregnancy
Association of gestational diabetes with long‐term risk of premature mortality, and cardiovascular outcomes and risk factors: A retrospective cohort analysis in the UK Biobank
Main finding · Premature mortalityResult — go to the resultHazard ratio 1.44 95% CI 1.12–1.86Authors' conclusion
Women with GDM are at increased risk of premature death and have increased CV risk, emphasizing the importance of interventions to prevent GDM. If GDM develops, the diagnosis represents an opportunity for future surveillance and intervention to reduce CVD risk factors, prevent CVD and improve long-term health.
Study context
- Population
- Parous women recruited to the UK Biobank cohort 2006–2010, followed from first delivery until 31 October 2021
- Participants
- 220,726 women9,694,090 person-years
- Exposure
- Gestational diabetes mellitus (GDM) vs no GDM
- GDMn = 1,225
- Outcome
- Premature mortality
Methodological detailsUK Biobank, linked to Hospital Episode Statistics and mortality registries, multivariate Cox proportional hazard models
- UK Biobank
- Linked to Hospital Episode Statistics and mortality registries
- Multivariate Cox proportional hazard models
Main finding
As reported in the abstract
Hazard ratio
1.44
95% CI 1.12–1.86
GDMvs No GDM
HR 1.44 (95% CI 1.12–1.86)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD-related death | 2.38 (1.63–3.48) | |
| Incident total CVD | 1.50 (1.30–1.74) | |
| Non-fatal CVD | 1.41 (1.20–1.65) | |
| Diabetes | 14.37 (13.51–15.27) | |
| Hypertension | 1.49 (1.38–1.60) | |
| Dyslipidaemia | 1.30 (1.22–1.39) | |
| 0.050.21520Hazard ratio (log scale) |
Total CVD by later diabetes (GDM subgroups)
- Total CVD risk greater in women with GDM who did not later develop diabetes than in those with GDM and diabetes
Original publication
Association of gestational diabetes with long‐term risk of premature mortality, and cardiovascular outcomes and risk factors: A retrospective cohort analysis in the UK Biobank. Diabetes Obes Metab. Published 28 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →