Gestational diabetes & diabetes in pregnancy
Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women
Authors' conclusion
These results extend our previous findings from pregnancy and first postpartum year demonstrating that still at 5 years postpartum, healthy lifestyle is associated with a lower risk of prediabetes/diabetes only among women at the highest genetic risk of type 2 diabetes.
Study context
- Population
- High-risk women (BMI ≥30 kg/m² and/or prior GDM) from the Finnish RADIEL GDM prevention trial, 5 years postpartumgenetic and glycemic data
- Participants
- 314 women
- Comparison
- Healthy Lifestyle Score (HLS) and its interaction with type 2 diabetes polygenic risk score (PRS) on glycemic abnormalities
- Primary endpoint
- Glycemic abnormalities (prediabetes/diabetes); modification of the HLS association by T2D PRS
- Follow-up
- 5 years postpartum
Methodological details5-year postpartum follow-up
- 5-year postpartum follow-up
Primary result
As reported in the abstract
Glycemic abnormalities
- Interaction between HLS and T2D PRS on glycemic abnormalities
- p=0.03
- HLS associated with reduced risk of glycemic abnormalities only among women at highest genetic risk (PRS tertiles)
- p=0.008
Further findings
Glycemic abnormalities in total sample · 5 years postpartum
- T2D PRS not associated with glycemic abnormalities
- HLS not associated with glycemic abnormalities in total sample
Original publication
Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women. BMJ Open Diabetes Res Care. Published 17 April 2024. doi:10.
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