Gestational diabetes & diabetes in pregnancy

Mean Glucose and Gestational Weight Gain as Predictors of Large-for-Gestational-Age Infants in Pregnant Women with Type 1 Diabetes Using Continuous Glucose Monitoring

Diabetes Technol TherPublished Cohort study

Main finding · Mean glucoseResult — go to the resultDifference 0.4 mmol/L

Authors' conclusion

Women with T1D delivering LGA infants achieved glycemic targets later than women delivering AGA infants. Mean glucose and gestational weight gain were independent predictors for delivering LGA infants. Infants born LGA remained larger postdelivery compared with infants born AGA.

Study context

Population
Pregnant women with T1D using isCGM from conception until delivery
Participants
111 women
Exposure
Women delivering large-for-gestational-age (LGA) vs appropriate-for-gestational-age (AGA) infants
  • LGAn = 59
Outcome
Glycemic metrics during pregnancy (mean glucose, TIRp, time above/below range, CV) compared between women delivering LGA and AGA infants; predictors of LGA infants

Main finding

Mean glucose · 11-33 weeks

Difference

0.4 mmol/L

P = 0.01

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeLGAAGAP value
Infant weight · 3 months postdeliveryHigher in infants born LGA6360 ± 784 g5988 ± 894P = 0.04

Original publication

Mean Glucose and Gestational Weight Gain as Predictors of Large-for-Gestational-Age Infants in Pregnant Women with Type 1 Diabetes Using Continuous Glucose Monitoring. Diabetes Technol Ther. Published 22 April 2024. doi:10.1089/dia.2023.0583

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