Gestational diabetes & diabetes in pregnancy
Considering gestational diabetes and gestational hypertension history across two pregnancies in relationship to cardiovascular disease development: A retrospective cohort study
Authors' conclusion
Health care providers and mothers should consider a complete history of GDM/GHTN occurrences to ascertain the importance and urgency of preventive action.
Study context
- Population
- Women with two singleton pregnancies, Quebec; cohort inception 1990–2012, outcomes 1990–2019
- Participants
- 431,980 women
- Exposure
- Number of GDM/GHTN occurrences over two pregnancies vs no GDM/GHTN in either pregnancy
- Outcome
- Cardiovascular disease (CVD): composite of MI, stroke and angina requiring hospitalization and/or causing death
- Follow-up
- Median 16.4 years
Methodological detailsQuebec-based, Cox proportional hazards models, adjusted
- Quebec-based
- Cox proportional hazards models, adjusted
Main finding
As reported in the abstract
CVD
Each group vs no GDM/GHTNHazard ratio (95% CI)
One occurrenceincreased CVD hazards by 47%
1.47(1.35–1.61)
Two occurrencesnearly doubled hazards
1.91(1.68–2.17)
Three or moreapproximately tripled CVD hazards
2.93(2.20–3.90)
Observational data: associations, not effects.
Further findings
Individual components of the composite (MI, stroke, angina)
- Individual components of the composite demonstrated similar findings
Original publication
Considering gestational diabetes and gestational hypertension history across two pregnancies in relationship to cardiovascular disease development: A retrospective cohort study. Diabetes Res Clin Pract. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →