Gestational diabetes & diabetes in pregnancy
Risk of Gestational Diabetes in Women With Polycystic Ovary Syndrome (PCOS) Based on Body Mass Index: The Japan Environment and Children's Study
Authors' conclusion
The impact of PCOS on GDM occurrence depended on the prepregnancy BMIs, which may facilitate personalized preconception counseling among women with PCOS.
Study context
- Population
- Singleton pregnancies in the Japan Environment and Children's Study (JECS), Japan, 2011–2014; excluded: first-trimester HbA1c ≥6.5%, history of DM or steroid use during pregnancy; Body mass index (BMI) groups G1 (<18.5), G2 (18.5–19.99), G3 (20.0–22.99), G4 (23.0–24.99), G5 (≥25.0 kg/m²)
- Participants
- 92,774 participants
- Exposure
- PCOS vs no PCOS, by prepregnancy BMI category
- PCOS(+)n = 2,012
- Outcome
- Early-onset (Ed) and late-onset (Ld) GDM by prepregnancy BMI group
Methodological detailsbirth cohort, multiple logistic regression
- Birth cohort
- Multiple logistic regression
Main finding
As reported in the abstract
Effect of PCOS on Ed and Ld GDM by BMI group
PCOS(+) vs PCOS(−)Adjusted odds ratio (95% CI)
G4, Ed GDM
3.27(1.29–8.29)
G5, Ed GDM
2.48(1.53–4.02)
G5, Ld GDM
1.94(1.23–3.07)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| GDM occurrence overallHigher with PCOS | P < 0.001 |
Original publication
Risk of Gestational Diabetes in Women With PCOS Based on Body Mass Index: The Japan Environment and Children's Study. J Clin Endocrinol Metab. Published 4 May 2024. doi:10.
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