Gestational diabetes & diabetes in pregnancy
Course of Pregnancies and Occurrence of Acute Pancreatitis in Women With Chylomicronemia
Authors' conclusion
In this study, pregnant women with chylomicronemia had a 30-fold (MCS) to 120-fold (FCS) higher occurrence of AP compared to the general population. Chylomicronemia per se does not seem to influence fetal development.
Study context
- Population
- Pregnancies in European and North American women with a history of chylomicronemia (TG >10 mmol/L)
- Participants
- 49 participants116 pregnancies
- Exposure
- Familial chylomicronemia syndrome (FCS) vs multifactorial chylomicronemia syndrome (MCS)
- FCSn = 20
- MCSn = 29reference
- Outcome
- Occurrence of acute pancreatitis (AP) during pregnancy
Methodological detailsretrospective review, European and North American women
- Retrospective review
- European and North American women
Main finding
As reported in the abstract
Women with ≥1 AP episode during pregnancy
P = 0.01
Observational data: associations, not effects.
Further findings
Pregnancies with AP
P = 0.02
Pregnancy-related AP occurring in primigravida women (share of all AP)
Premature deliveries · elevated in both groups
P = 0.01
Miscarriages and fetal failure to thrive
- Miscarriages (11.8% vs 10.7%) not significantly different between the 2 cohorts
- Fetal failure to thrive (5.9% vs 9.2%) not significantly different between the 2 cohorts
- Groups not assigned to values in abstract
Original publication
Course of Pregnancies and Occurrence of Acute Pancreatitis in Women With Chylomicronemia. J Clin Endocrinol Metab. Published 15 July 2025. doi:10.
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