Gestational diabetes & diabetes in pregnancy
Association of Gestational Diabetes With the Dynamic Changes of Gut Microbiota in Offspring From 1 to 6 Months of Age
An erratum to this article was published (J Clin Endocrinol Metab, 21 Dec 2023 ↗)
Authors' conclusion
Maternal GDM was associated not only with the community structure and composition in the gut microbiota of offspring at a specific time point, but also with the differential changes from birth to infancy. Altered colonization of the GDM infants' gut microbiota might affect their growth. Our findings underscore the critical impact of GDM on the formation of early-life gut microbiota and on the growth and development of infants.
Study context
- Population
- Mother-infant dyads; infant fecal samples at 1 month (M1) and 6 months (M6) of age, gut microbiota profiled by 16S rRNA gene sequencing
- Participants
- 73 mother-infant dyads
- Exposure
- Gestational diabetes mellitus (GDM) vs non-GDM mothers' offspring
- GDMn = 34
- non-GDMn = 39reference
- Outcome
- Gut microbiota diversity and composition
- Follow-up
- M1 and M6
Main finding
As reported in the abstract
M1 and M6
- Differential structures and composition at M6 between the 2 groups
- P < .05
- At M6, lower diversity in GDM infants, with depleted and enriched gut microbes
- 6 depleted, 10 enriched
- Dynamic changes in alpha diversity from M1 to M6 significantly different by GDM status
- P < .05
Observational data: associations, not effects.
Further findings
- Altered gut bacteria in GDM infants were correlated with infants' growth
Original publication
Association of Gestational Diabetes With the Dynamic Changes of Gut Microbiota in Offspring From 1 to 6 Months of Age. J Clin Endocrinol Metab. Published 4 March 2023. doi:10.
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