Gestational diabetes & diabetes in pregnancy
Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring
Main finding · Any isolated CHDResult — go to the resultOdds ratio 3.77 95% CI 3.26–4.36Authors' conclusion
This study found that maternal T1D was associated with increased risk for most types of CHD in offspring, while obesity and overweight were associated with increased risk for complex defects and outflow tract obstruction and decreased risk for ventricular septal defects. These different risk profiles of T1D and overweight and obesity may suggest distinct underlying teratogenic mechanisms.
Study context
- Population
- All children born in Finland 2006–2016 and their mothers
- Participants
- 620,751 children
- Exposure
- Maternal diabetes status and prepregnancy body mass index (BMI) categories vs no diabetes and normal BMI
- Outcome
- Odds ratios (ORs) of isolated congenital heart defects (CHDs) in children
Methodological detailsnationwide, birth cohort, Data analyzed January 2022 to November 2023
- Nationwide
- Birth cohort
- Data analyzed January 2022 to November 2023
Main finding
Any isolated CHD
Odds ratio
3.77
95% CI 3.26–4.36
T1Dvs No diabetes
OR 3.77 (95% CI 3.26–4.36)
As reported in the abstract
- Children with an isolated CHD
- 10 254 (1.7%)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| CHD subgroups with maternal T1DT1Dvs No diabetesLowest of OR range | OR (other septal defects) 3.28 (95% CI 1.55–6.95) | |
| CHD subgroups with maternal T1DT1Dvs No diabetesHighest of OR range | OR (transposition of great arteries) 7.39 (95% CI 3.00–18.21) | |
| CHD subgroups with maternal overweightOverweightvs Normal | OR (left ventricular outflow tract obstruction) 1.28 (95% CI 1.10–1.49) | |
| CHD subgroups with maternal overweightOverweightvs Normal | OR (ventricular septal defects) 0.92 (95% CI 0.86–0.98) | |
| CHD subgroups with maternal obesityObesityvs Normal | OR (complex defects) 2.70 (95% CI 1.14–6.43) | |
| CHD subgroups with maternal obesityObesityvs Normal | OR (right outflow tract obstruction) 1.31 (95% CI 1.09–1.58) | |
| 0.050.21520Ratio (log scale) |
CHD subgroups with maternal T1D
- T1D associated with increased odds in 6 of 9 CHD subgroups
Original publication
Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring. JAMA Netw Open. Published 2 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →