Gestational diabetes & diabetes in pregnancy
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs
Authors' conclusion
Our findings indicate that there is a small-to-moderate association between MDM and ADHD, whereas the association between GDM and ADHD is unlikely to be causal.
Study context
- Population
- Mother-child pairs in Hong Kong, New Zealand, Taiwan, Finland, Iceland, Norway and Sweden, 2001–2014, follow-up until 2020
- Participants
- over 3.6 million mother-child pairs
- Exposure
- Maternal diabetes vs unexposed
- Outcome
- ADHD in offspring
- Follow-up
- Until 2020
Methodological detailslinked mother-child pairs data, Cox proportional hazards regression, sibling analysis
- Linked mother-child pairs data
- Cox proportional hazards regression
- Sibling analysis
Main finding
As reported in the abstract
ADHD
Each group vs unexposedPooled hazard ratio (95% CI)
Any MDM
1.16(1.08–1.24)
GDM
1.10(1.04–1.17)
PGDM
1.39(1.25–1.55)
Observational data: associations, not effects.
Further findings
| Outcome | Pooled HR (95% CI) | |
|---|---|---|
| ADHD in siblings with discordant exposure to GDMGDMvs UnexposedSibling comparison | 1.05 (0.94–1.17) | |
| 0.512Pooled hazard ratio (log scale) |
Attention-deficit/hyperactivity disorder (ADHD) in siblings with discordant exposure to gestational diabetes mellitus (GDM)
- Siblings with discordant GDM exposure had similar ADHD risks, suggesting confounding by unmeasured shared familial factors
Original publication
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs. Nat Med. Published 8 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →