Gestational diabetes & diabetes in pregnancy
Triglycerides Mediate the Relationship Between Maternal Free Thyroxine and Birth Weight: A Prospective Cohort Study from China
Authors' conclusion
High maternal TG levels may play substantial mediating roles in the relationship between low fT4 levels in early pregnancy and increased birth weight and a higher risk of LGA. Further, the occurrence of fetal overgrowth may also be influenced by possible synergistic effects between fT4 and TG.
Study context
- Population
- Pregnant Chinese women treated at a tertiary obstetric center, January 2016 to December 2018, with complete medical records
- Participants
- 35,914 participants
- Exposure
- Maternal free thyroxine (fT4) and birth weight/LGA, with maternal triglyceride (TG) as mediator
- Outcome
- Mediating role of maternal TG in the association between maternal fT4 and birth weight (and LGA)
- Follow-up
- Early pregnancy exposure
Methodological detailscausal mediation analysis, four-way decomposition model
- Causal mediation analysis
- Four-way decomposition model
Main finding
As reported in the abstract
Four-way decomposition of the effect of fT4 on birth weight Z score with TG as mediator
- Proportion of total effect of fT4 on birth weight via TG mediation
- 21.6%
- Proportion of total effect of fT4 on LGA via TG mediation
- 20.7%
- Proportion of total effect of fT4 on birth weight via fT4–TG interaction
- 13.6%
- Proportion of total effect of fT4 on LGA via fT4–TG interaction
- 41.6%
- Proportion of total association with birth weight reducible by eliminating TG effect
- 36.1%
- Proportion of total association with LGA reducible by eliminating TG effect
- 65.1%
Observational data: associations, not effects.
Original publication
Triglycerides Mediate the Relationship Between Maternal Free Thyroxine and Birth Weight: A Prospective Cohort Study from China. Thyroid. Published 13 April 2023. doi:10.
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