Gestational diabetes & diabetes in pregnancy
Association Between Maternal Thyroid Function in Early Pregnancy and Gestational Diabetes: A Prospective Cohort Study
Authors' conclusion
High TSH might be associated with increased risk of GDM.
Study context
- Population
- Pregnant women in the China Birth Cohort Study (CBCS), tertiary maternal and child health hospital, February 2018 to December 202036,256 recruited
- Participants
- 26,742 women
- Exposure
- Thyroid function in early pregnancy and gestational diabetes mellitus (GDM)
- Outcome
- GDM
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Increased thyroid-stimulating hormone (TSH) and GDM, aOR
1.030
95% CI 1.007, 1.054P = .012
SCH and GDM, aOR
1.211
95% CI 1.010, 1.451P = .039
GDM incidence
3985
14.90%
Observational data: associations, not effects.
Further findings
Maternal age, GDM vs no GDM · women with GDM were older
P < 0.001
Nonlinear relationship between TSH and GDM
- Nonlinear TSH–GDM relationship: GDM rose with TSH when TSH ≤ 1.24 mIU/L; trend not obvious when TSH > 1.24 mIU/L
- P < 0.05
Original publication
Association Between Maternal Thyroid Function in Early Pregnancy and Gestational Diabetes: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 30 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →