Gestational diabetes & diabetes in pregnancy
Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Mellitus Results in Similar Newborn Adiposity
Authors' conclusion
A ∼100 g/day difference in carbohydrate intake did not result in between-group differences in NB%fat, cord C-peptide level, maternal 24-h glycemia, %TIR, or insulin resistance indices in diet-controlled GDM.
Study context
- Population
- Women with diet-controlled gestational diabetes mellitus (GDM), randomized after diagnosis at ∼28–30 weeks' gestation through delivery; BMI 32 ± 1 kg/m² (mean ± SEM)23 per group analysed
- Participants
- 59 women
- Comparison
- Higher-complex-carbohydrate, lower-fat CHOICE diet vs conventional lower-carbohydrate, higher-fat LC/CONV diet
- CHOICEn = 23
- LC/CONVn = 23reference
- Primary endpoint
- Newborn adiposity (NB%fat; powered outcome), by air displacement plethysmography
- Follow-up
- 13.4 ± 0.4 days
Methodological detailsall meals provided
- All meals provided
Primary result
As reported in the abstract
Further findings
Birth weight
Birth weight
- Birth weight not different between groups
Cord C-peptide · delivery
- Cord C-peptide levels not different between groups
Continuous glucose monitor (CGM) fasting, 1-h and 2-h postprandial glucose, %TIR and 24-h glucose AUC · 36-37 weeks of gestation
- CGM fasting, 1-h and 2-h postprandial glucose, %TIR and 24-h glucose AUC similar between diets
CGM %time >120 mg/dL, nocturnal glucose AUC and nocturnal %TIR (63-100 mg/dL) · 36-37 weeks of gestation
- %time >120 mg/dL statistically higher in CHOICE
- 8%
- Nocturnal glucose AUC higher in CHOICE
- Nocturnal %TIR (63-100 mg/dL) not different
Oral glucose tolerance test (OGTT) glucose and insulin levels · 36-37 weeks of gestation
- No between-group differences in OGTT glucose and insulin levels
Weight gain, physical activity and gestational age at delivery
- Weight gain, physical activity and gestational age at delivery similar
Original publication
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