Gestational diabetes & diabetes in pregnancy
Five-year follow-up of maternal and child health after gestational diabetes mellitus diagnosed using different glycaemic criteria: The GEMS follow-up study
Authors' conclusion
GDM diagnosis using the IADPSG criteria did not reduce maternal diabetes or child BMI five-years later, but was associated with other health benefits.
Study context
- Population
- Participants of the GEMS trial (women and their children), allocated to GDM diagnosis by different glycaemic criteria869 women, 833 children assessed
- Participants
- 1,206 participants
- Comparison
- GDM diagnosis using IADPSG criteria vs New Zealand criteria
- Primary endpoint
- Maternal T2D/prediabetes and child BMI z-score
- Follow-up
- Five years
Methodological detailsfive-year follow-up
- Five-year follow-up
Primary result
As reported in the abstract
Maternal diabetes/prediabetes; child BMI z-score
| Group | Value | Child BMI z-score |
|---|---|---|
| IADPSG criteria | 20.5 % | 0.36 |
| New Zealand criteria | 16.5 % | 0.50 |
Value
IADPSG criteria20.5 %
New Zealand criteria16.5 %
Child BMI z-score
IADPSG criteria0.36
New Zealand criteria0.50
- IADPSG criteria vs New Zealand criteria: P = 0.10 — maternal diabetes/prediabetes; similar
- IADPSG criteria vs New Zealand criteria: P = 0.14 — child BMI z-score; similar
Further findings
Maternal and child secondary outcomes
- Women with IADPSG criteria had less hypertension and pharmaceutical use but more GDM in subsequent pregnancies vs New Zealand criteria
- Children in IADPSG criteria group had lower rates of overweight and neurodevelopmental impairment
Treated vs untreated mild gestational hyperglycaemia
- Maternal diabetes rates and child BMI z-scores were similar between treated and untreated mild gestational hyperglycaemia
Original publication
Five-year follow-up of maternal and child health after gestational diabetes mellitus diagnosed using different glycaemic criteria: The GEMS follow-up study. Diabetes Res Clin Pract. Published 26 October 2025. doi:10. 1016/ j. diabres. 2025. 112966
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