Gestational diabetes & diabetes in pregnancy

Five-year follow-up of maternal and child health after gestational diabetes mellitus diagnosed using different glycaemic criteria: The GEMS follow-up study

Diabetes Res Clin PractPublished Follow-up study of the GEMS randomised trial

Authors' conclusion

GDM diagnosis using the IADPSG criteria did not reduce maternal diabetes or child BMI five-years later, but was associated with other health benefits.

Study context

Population
Participants of the GEMS trial (women and their children), allocated to GDM diagnosis by different glycaemic criteria869 women, 833 children assessed
Participants
1,206 participants
Comparison
GDM diagnosis using IADPSG criteria vs New Zealand criteria
Primary endpoint
Maternal T2D/prediabetes and child BMI z-score
Follow-up
Five years
Methodological detailsfive-year follow-up
  • Five-year follow-up

Primary result

As reported in the abstract

Maternal diabetes/prediabetes; child BMI z-score
GroupValueChild BMI z-score
IADPSG criteria20.5 %0.36
New Zealand criteria16.5 %0.50

Value

IADPSG criteria20.5 %
New Zealand criteria16.5 %

Child BMI z-score

IADPSG criteria0.36
New Zealand criteria0.50
  • IADPSG criteria vs New Zealand criteria: P = 0.10 — maternal diabetes/prediabetes; similar
  • IADPSG criteria vs New Zealand criteria: P = 0.14 — child BMI z-score; similar

Further findings

Maternal and child secondary outcomes

Women with IADPSG criteria had less hypertension and pharmaceutical use but more GDM in subsequent pregnancies vs New Zealand criteria
Children in IADPSG criteria group had lower rates of overweight and neurodevelopmental impairment

Treated vs untreated mild gestational hyperglycaemia

Maternal diabetes rates and child BMI z-scores were similar between treated and untreated mild gestational hyperglycaemia

Original publication

Five-year follow-up of maternal and child health after gestational diabetes mellitus diagnosed using different glycaemic criteria: The GEMS follow-up study. Diabetes Res Clin Pract. Published 26 October 2025. doi:10.1016/j.diabres.2025.112966

Composed by AI from the published abstract and checked against it. How Briefs are made →

Get them every week

New studies on this topic in My Week and in your Monday e-mail.

We e-mail you a sign-in link and a code. No password, no spam.