Gestational diabetes & diabetes in pregnancy
Bile acid metabolites in early pregnancy and risk of gestational diabetes mellitus: Results from a prospective cohort study
Authors' conclusion
This study indicated that, the levels of circulating bile acids in early pregnancy were associated with risk of GDM, independent of GDM risk factors. Most GDM-associated bile acids were primary conjugated and secondary unconjugated bile acids.
Study context
- Population
- Pregnant women at early pregnancy, Jiashan Birth Cohort
- Participants
- 645 women
- Exposure
- Early-pregnancy plasma bile acid metabolites and gestational diabetes mellitus (GDM) risk
- Outcome
- GDM
- Follow-up
- Mid-late pregnancy
Methodological detailsmeta-analysis of prospective studies
- Meta-analysis of prospective studies
Main finding
As reported in the abstract
Taurocholic acid (TCA), positive association with GDM (linear): OR
2.07 (1.05, 3.96); P = 0.030 (95% CI)
Lithocholic acid (LCA), negative association with GDM (linear): OR
0.83 (0.68, 1.01); P = 0.065 (95% CI)
Observational data: associations, not effects.
Further findings
Univariate models: metabolites associated with GDM
- Eight metabolites associated with GDM (cholic acid, TCA, glycocholic acid, glycochenodeoxycholic acid, deoxycholic acid, LCA, ursodeoxycholic acid, taurolithocholic acid), all P <0.05
- 8
Meta-analysis of 5 studies: bile acid and GDM
- RR
- 2.43 (1.95, 3.03)
Original publication
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