Gestational diabetes & diabetes in pregnancy
Higher early pregnancy plasma myo ‐inositol associates with increased postprandial glycaemia later in pregnancy: Secondary analyses of the NiPPeR randomized controlled trial
Authors' conclusion
To our knowledge, our study provides the first evidence that increasing first trimester plasma myo-inositol may slightly exacerbate later pregnancy post-challenge glycaemia, indicating that the optimal timing for starting prenatal myo-inositol supplementation needs further investigation.
Study context
- Population
- Women recruited from Singapore, UK and New Zealand for the NiPPeR study (myo-inositol-containing supplement starting preconception)
- Participants
- 585 women
- Comparison
- Plasma myo-inositol concentrations at 7 and 28 weeks' gestation in relation to 28-week glycaemia and insulin indices
- Primary endpoint
- 28-week plasma glucose (fasting, 1 h and 2 h in 75 g OGTT) and insulin indices
- Follow-up
- 28 weeks' gestation
Methodological detailsmultinational
- Multinational
Primary result
As reported in the abstract
Higher 7-week myo-inositol and 1 h plasma glucose (PG), βadj (95% CI) loge mmol/L per loge μmol/L
0.05
0.01, 0.09p = .022
Higher 7-week myo-inositol and 2 h PG, βadj
0.08 (0.03, 0.12), p = .001 (95% CI)
Increase in 2 h PG for an average 7-week myo-inositol increase of 23.4 μmol/L with supplementation
0.39 mmol/L
Further findings
28-week Stumvoll index (first phase), approximation of insulin secretion
- Higher 7-week myo-inositol associated with lower Stumvoll index, βadj
- −0.08 (−0.15, −0.01), p = .020 (95% CI)
- No association with 28-week Matsuda insulin sensitivity index
GDM risk, birthweight and cord C-peptide
- No association of 7-week myo-inositol with GDM risk, birthweight or cord C-peptide
In-silico modelling by ethnicity
- Higher 28-week myo-inositol associated with lower gestational glycaemia in White but not Asian women, after controlling for 7-week myo-inositol effects
Original publication
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