Gestational diabetes & diabetes in pregnancy
Tight versus less tight glycaemic targets for women with gestational diabetes mellitus: a randomised controlled trial
Primary result · LGAResult — go to the resultAdjusted relative risk 0.61 95% CI 0.42–0.89Authors' conclusion
Tight glycemic targets in GDM lower the risk of LGA births, cesarean delivery, and excess maternal weight gain without increasing severe adverse events, though they necessitate more frequent insulin therapy.
Study context
- Population
- Women with gestational diabetes mellitus (GDM), singleton pregnancies, 12–31 weeks' gestation626 completed
- Participants
- 650 women
- Comparison
- Tight vs less tight glycaemic targets in GDM
- Primary endpoint
- Incidence of large-for-gestational-age (LGA) infants
Methodological detailssingle-centre, open-label
- Single-centre
- Open-label
Primary result
LGA
Adjusted relative risk
0.61
95% CI 0.42–0.89
P = 0.010
By group
Tightvs Less tight
aRR 0.61 (95% CI 0.42–0.89); P = 0.010
As reported in the abstract
Secondary outcomes
Caesarean delivery
aRR 0.63 · P = 0.012
Insulin use
aRR 1.67 · P = 0.005
Gestational weight gain · lower with Tight
P = 0.006
Safety
- Serious complications and maternal hypoglycaemia rates were low and comparable
Original publication
Tight versus less tight glycaemic targets for women with gestational diabetes mellitus: a randomised controlled trial. Diabetes Res Clin Pract. Published 11 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →