Gestational diabetes & diabetes in pregnancy

Simplified gestational diabetes screening with a triaging fasting plasma glucose reduces the burden of oral glucose tolerance tests during pregnancy – A large tertiary comparative cohort study

Diabetes Res Clin PractPublished Retrospective cohort study

Authors' conclusion

The simplified GDM screening strategy for significantly reduced OGTTs by over 80% without impacting perinatal outcomes. It suggests that prospective studies are necessary to further evaluate this approach.

Study context

Population
Singleton births from 20 weeks' gestation; excluded: no diagnostic glucose results from 13 weeks' gestation or incomplete screeningof 15,138 pregnancies
Participants
12,035 births
Exposure
Simplified GDM screening with triaging fasting plasma glucose (FPG) vs conventional screening
  • Simplifiedn = 4,650
  • Conventionaln = 7,385reference
Outcome
OGTT avoided
Methodological detailscomparative, tertiary centre
  • Comparative
  • Tertiary centre

Main finding

As reported in the abstract

Simplified

82.9 %

Observational data: associations, not effects.

Further findings

GDM prevalence · lower with Simplified

P < 0.001

Perinatal outcomes, incl. large-for-gestational-age infants

Perinatal outcomes, including the rate of large-for-gestational-age infants, were similar between the groups

Original publication

Simplified gestational diabetes screening with a triaging fasting plasma glucose reduces the burden of oral glucose tolerance tests during pregnancy – A large tertiary comparative cohort study. Diabetes Res Clin Pract. Published 1 February 2024. doi:10.1016/j.diabres.2024.111120

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