Gestational diabetes & diabetes in pregnancy
In utero exposure to maternal diabetes or hypertension and childhood hypothalamic gliosis
Authors' conclusion
We concluded that children exposed to maternal DM in utero display evidence of hypothalamic gliosis, suggesting that gestational DM may have a distinct influence on offspring's brain development and, by extension, children's long-term metabolic health.
Study context
- Population
- Children aged 9–11 years enrolled in the ABCD Study
- Participants
- 306 children
- Exposure
- In utero exposure to maternal DM or hypertension (HTN) vs unexposed
- DM-exposedn = 49
- HTN-exposedn = 53
- Unexposedn = 204reference
- Outcome
- MBH/amygdala (AMY) T2 signal ratio on brain magnetic resonance imaging (MRI) (marker of MBH gliosis)
Methodological detailsage- and sex-matched (2:1), subsample of the ABCD Study
- Age- and sex-matched (2:1)
- Subsample of the ABCD Study
Main finding
As reported in the abstract
MBH/AMY T2 signal ratio
β
0.05
P = 0.02
DM-exposed
β
0.03
P = 0.13
HTN-exposed
- Overall effect of group, F(2,300)
- 3.51 (p = 0.03)
Observational data: associations, not effects.
Original publication
In utero exposure to maternal diabetes or hypertension and childhood hypothalamic gliosis. Int J Obes (Lond). Published 25 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →