Gestational diabetes & diabetes in pregnancy
Prenatal Exposure to Gestational Diabetes Mellitus Is Associated With Greater Pre‐Pubertal Body Mass Index (BMI) Growth and Faster Post‐Pubertal Cortical Thinning During Peri‐Adolescence
Authors' conclusion
Prenatal GDM exposure is associated with greater pre-pubertal increases in BMI and faster post-pubertal cortical thinning in youth aged between 9 and 15.
Study context
- Population
- Children aged 9–10 years from the Adolescent Brain and Cognitive Development (ABCD) Study, followed yearly through 4-year follow-up
- Participants
- 9,583 children
- Exposure
- Prenatal gestational diabetes mellitus (GDM) exposure vs no exposure
- Outcome
- Trajectories of BMI and brain structural measures (MRI)
- Follow-up
- through 4-year follow-up
Methodological detailslongitudinal, mixed-effects models, linear spline with knot at puberty onset
- Longitudinal
- Mixed-effects models
- Linear spline with knot at puberty onset
Main finding
As reported in the abstract
Interaction of exposure by age in change in BMI, β
0.032 (0.008, 0.056), p = 0.009 (95% CI)
Interaction of exposure by age in mean cortical thickness, β
−0.038 (−0.071, −0.004), p = 0.027 (95% CI)
BMI interaction driven by greater pre-pubertal increases in BMI, β
0.051 (0.002, 0.100), p = 0.043 (95% CI)
Cortical thickness interaction driven by faster post-pubertal declines in cortical thickness among GDM-exposed offspring, β
−0.051 (−0.095, −0.007), p = 0.046 (95% CI)
Observational data: associations, not effects.
Original publication
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