Gestational diabetes & diabetes in pregnancy
Adverse perinatal outcomes in gestational diabetes mellitus with and without SARS-CoV-2 infection during pregnancy: results from two nationwide registries in Germany
Authors' conclusion
GDM with SARS-CoV-2 infection in pregnancy is associated with an increased risk of adverse fetal and neonatal outcomes as compared with GDM without SARS-CoV-2 infection.
Study context
- Population
- Pregnant women with gestational diabetes mellitus (GDM) in two German registries
- Participants
- 409 vs 4,598
- Exposure
- GDM with SARS-CoV-2 infection vs GDM without infection
- CRONOSn = 409
- GestDiabn = 4,598reference
Methodological detailstwo nationwide registries, CRONOS: multicenter prospective observational study, historical comparison (GestDiab 2018-2019)
- Two nationwide registries
- CRONOS: multicenter prospective observational study
- Historical comparison (GestDiab 2018-2019)
Main finding
As reported in the abstract
CRONOS vs GestDiabAdjusted odds ratio (95% CI)
Combined primary outcome
1.48(1.11–1.97)
Preterm birth
1.50(1.07–2.10)
Observational data: associations, not effects.
Secondary outcomes
Fasting glucose
Maternal age
BMI
- Fasting glucose — Each 0.1 mmol/L increase in fasting glucose and preterm birth risk, CRONOS only
- aOR 1.05 (95% CI 1.01 to 1.09)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Adverse perinatal outcomes in gestational diabetes mellitus with and without SARS-CoV-2 infection during pregnancy: results from two nationwide registries in Germany. BMJ Open Diabetes Res Care. Published 25 January 2024. doi:10.
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