Gestational diabetes & diabetes in pregnancy
Combined impact of Hepatitis B virus and gestational diabetes mellitus on ultrasound-measured fetal growth and adverse perinatal outcomes: A seven-year retrospective study
Authors' conclusion
Both maternal HBV infection and GDM are independently associated with adverse perinatal outcomes. Their combination further increases the risk of adverse perinatal outcomes.
Study context
- Population
- Pregnant women with hepatitis B virus (HBV) infection and/or Gestational diabetes mellitus (GDM) delivering at Women's Hospital, Zhejiang University, January 2015–September 2022in final analysis
- Participants
- 1,633 women
- Exposure
- HBV infection and GDM vs neither HBV infection nor GDM
- HBV + GDMn = 409
- HBV onlyn = 396
- GDM onlyn = 430
- Without HBV and GDMn = 398reference
- Outcome
- Fetal growth and adverse perinatal outcomes, HBV + GDM vs without HBV and GDM
Methodological detailssingle-centre, seven-year, Linear and logistic regression models
- Single-centre
- Seven-year
- Linear and logistic regression models
Main finding
As reported in the abstract
HBV + GDM vs Without HBV and GDMOdds ratio (95 % CI)
Fetal femur length overgrowth
2.88(1.13 ∼ 7.35)
Placental abruption
3.64(1.18 ∼ 11.22)
Macrosomia
4.19(1.66 ∼ 10.56)
Observational data: associations, not effects.
Original publication
Combined impact of Hepatitis B virus and gestational diabetes mellitus on ultrasound-measured fetal growth and adverse perinatal outcomes: A seven-year retrospective study. Diabetes Res Clin Pract. Published 13 January 2024. doi:10.
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