Gestational diabetes & diabetes in pregnancy
Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus
Authors' conclusion
Women with previous GDM showed a reduced GLP-1 response in relation to PG and insulin concentrations indicating early abnormalities in glucose metabolism. However, the altered GLP-1 response to oral glucose did not predict progression to pre-diabetes and type 2 diabetes in the first 5 years after GDM.
Study context
- Population
- Women after pregnancy with previous gestational diabetes mellitus (GDM) or normal glucose tolerance, PPSDiab study
- Participants
- 129 vs 67
- Exposure
- Women with previous GDM vs women with normal glucose tolerance in pregnancy
- Previous GDMn = 129
- Controlsn = 67reference
- Outcome
- Association of GLP-1 response to oral glucose (OGTT) with parameters of glycemic control
Methodological detailscase-control comparison at baseline, 5-year follow-up
- Case-control comparison at baseline
- 5-year follow-up
Main finding
As reported in the abstract
GLP-1, PG and insulin response during OGTT (AUC 0-120 min) · baseline
- AUC of plasma glucose (PG) and insulin, but not GLP-1, differed significantly between post-GDM women and controls
- Previous GDM: significantly decreased GLP-1 response relative to PG and plasma insulin in second phase of oral glucose tolerance test (OGTT)
Observational data: associations, not effects.
Further findings
- Development of abnormal glucose metabolism in post-GDM women normoglycemic at baseline · 5 years — Previous GDM
- 19.0%
- Development of abnormal glucose metabolism in post-GDM women normoglycemic at baseline: n=58 normoglycemic at baseline
Development of abnormal glucose metabolism in post-GDM women normoglycemic at baseline · 5 years
- Total, first- and second-phase AUC GLP-1/PG and GLP-1/insulin ratios not associated with development of abnormal glucose tolerance
Original publication
Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus. BMJ Open Diabetes Res Care. Published 10 January 2024. doi:10.
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