Gestational diabetes & diabetes in pregnancy
Maternal and neonatal outcomes according to the timing of diagnosis of hyperglycaemia in pregnancy: a nationwide cross-sectional study of 695,912 deliveries in France in 2018
Authors' conclusion
Compared with GDM22-30, overt diabetes, GDM<22 and, to a lesser extent, GDM>30 were associated with poorer maternal-fetal outcomes.
Study context
- Population
- All deliveries after 22 gestational weeks (GW) in women without pre-existing diabetes recorded in 2018, France84,705 with hyperglycaemia
- Participants
- 695,912 women
- Exposure
- Subtypes of hyperglycaemia in pregnancy by timing of diagnosis vs gestational diabetes mellitus (GDM) diagnosed at 22–30 GW
- Outcome
- Maternal-fetal outcomes:
- Adjusted prevalence ratios
- Adjusted for maternal age
- Gestational age
- Socioeconomic status
Methodological detailsnationwide, French National Health Data System
- Nationwide
- French National Health Data System
Main finding
As reported in the abstract
Adjusted prevalence ratios vs GDM22-30, deliveries at ≥31 GW (significant after Holm-Bonferroni)
Each group vs GDM22-30Estimate (95% CI)
Overt diabetes
adjusted prevalence ratio, Caesarean section 1.54(1.39–1.72)
Overt diabetes
adjusted prevalence ratio, LGA infants 2.00(1.72–2.32)
Overt diabetes
adjusted prevalence ratio, Erb's palsy or clavicle fracture 6.38(2.42–16.8)
Overt diabetes
adjusted prevalence ratio, preterm birth 1.84(1.41–2.40)
Overt diabetes
adjusted prevalence ratio, neonatal hypoglycaemia 1.98(1.39–2.83)
GDM<22
adjusted prevalence ratio, LGA infants 1.10(1.06–1.14)
GDM<22
adjusted prevalence ratio, Erb's palsy or clavicle fracture 1.55(1.22–1.99)
GDM>30
adjusted prevalence ratio, LGA infants 1.44(1.37–1.52)
No hyperglycaemia
adjusted prevalence ratio, preeclampsia or eclampsia 0.74(0.69–0.79)
No hyperglycaemia
adjusted prevalence ratio, Caesarean section 0.80(0.79–0.82)
No hyperglycaemia
adjusted prevalence ratio, pregnancy and postpartum haemorrhage 0.93(0.89–0.96)
No hyperglycaemia
adjusted prevalence ratio, LGA neonate 0.67(0.65–0.69)
No hyperglycaemia
adjusted prevalence ratio, premature neonate 0.80(0.77–0.83)
No hyperglycaemia
adjusted prevalence ratio, neonatal hypoglycaemia 0.73(0.66–0.82)
Observational data: associations, not effects.
Further findings
Distribution of hyperglycaemia in pregnancy
| Outcome | Adjusted prevalence ratio (95% CI) | |
|---|---|---|
| Perinatal deathOvert diabetesvs GDM22-30Non-significant after Holm-Bonferroni adjustment | 5.06 (1.87–13.7) | |
| 0.050.21520Adjusted prevalence ratio (log scale) |
- Distribution of hyperglycaemia in pregnancy — Women with hyperglycaemia in pregnancy
- 84,705 (12.2%)
Deliveries at ≥37 GW
- Overall, results similar to deliveries at ≥31 GW
Original publication
Maternal and neonatal outcomes according to the timing of diagnosis of hyperglycaemia in pregnancy: a nationwide cross-sectional study of 695,912 deliveries in France in 2018. Diabetologia. Published 5 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →