Gestational diabetes & diabetes in pregnancy
Maternal Serum Polyols and Its Link to Gestational Diabetes Mellitus: A Population-Based Nested Case–Control Study
Authors' conclusion
Maternal circulating sugar alcohols levels during pregnancy were significantly associated with GDM. These findings provide the potential roles of polyols on maternal metabolic health during pregnancy.
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM); fasting maternal serum erythritol, sorbitol and xylitol quantified by time of flight mass spectrometry
- Participants
- 109 women
- Comparison
- Women with GDM vs without GDM
- Outcome
- Odds of GDM per 1-SD increment of Box-Cox-transformed serum polyol concentrations
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Erythritol: increased odds of GDM
43%
95% CI 1.07–1.92
Sorbitol: increased odds of GDM
155%
95% CI 1.77–3.69
Xylitol: decreased odds of GDM
25%
95% CI 0.57–1.00
Observational data: associations, not effects.
Further findings
Large for gestational age newborns per 1-SD increase of Box-Cox-transformed serum sorbitol
- Increased odds of large for gestational age newborns
- 52% (95% CI 1.00-2.30)
- Controlling for possible confounders
Original publication
Maternal Serum Polyols and Its Link to Gestational Diabetes Mellitus: A Population-Based Nested Case–Control Study. J Clin Endocrinol Metab. Published 8 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →