Gestational diabetes & diabetes in pregnancy
Weight retention and glucose intolerance in early postpartum after gestational diabetes
Authors' conclusion
Modifiable risk factors such as lifestyle, prepregnancy BMI, GWG, and mental health can be used to identify a subgroup of women with GDM at the highest risk of developing early PPWR, allowing for a more personalized follow-up.
Study context
- Population
- Women with a recent history of GDM, 75g OGTT at 6–16 weeks postpartum
- Participants
- 1,201 women
- Exposure
- High vs moderate vs no PPWR
- High PPWRn = 187
- Moderate PPWRn = 463
- Outcome
- Risk factors for early postpartum weight retention (PPWR) and glucose intolerance (GI)
- Follow-up
- 6-16 weeks postpartum
Methodological detailsmulticentre (n=8)
- Multicentre (n=8)
Main finding
As reported in the abstract
Early PPWR
Observational data: associations, not effects.
Further findings
| Outcome | High PPWR | Without PPWR | P value |
|---|---|---|---|
| GI by PPWRHigh PPWR vs Without PPWR | 33.7% | 24.9% | P = 0.020 |
- Depression, high PPWR vs PPWR <5 kg · 23.1% (43) vs. 16.0% (74)
- P = 0.035
- High-risk perception for diabetes in high PPWR
- 12.9% · 24 of 187
Glucose intolerance (all participants)
- Glucose intolerance (GI)
- 28.0% (336)
- Prediabetes
- 26.1% (313)
- Diabetes
- 1.9% (23)
Depression, high PPWR vs PPWR <5 kg
- High PPWR vs PPWR <5 kg: more impaired postpartum metabolic profile, less breastfeeding, higher anxiety levels, lower quality of life
High-risk perception for diabetes in high PPWR
- High PPWR more often willing to change lifestyle than moderate PPWR
Original publication
Weight retention and glucose intolerance in early postpartum after gestational diabetes. Eur J Endocrinol. Published 19 May 2023. doi:10.
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