Gestational diabetes & diabetes in pregnancy
Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus
Authors' conclusion
PFAS exposure is associated with glucose intolerance, insulin resistance, and β-cell dysfunction, thus increasing type 2 diabetes risk.
Study context
- Population
- Hispanic women with a history of gestational diabetes mellitus (GDM), followed from the third trimester of pregnancy to 12 years after delivery
- Participants
- 80 women
- Exposure
- Higher vs lower plasma PFAS concentrations
- Outcome
- Trajectories of diabetes indicators (from OGTT and intravenous glucose tolerance tests) in relation to PFAS
- Follow-up
- Pregnancy to 12 years after delivery
Methodological detailslongitudinal, linear mixed-effects model adjusted for age, breastfeeding status, daily total calorie intake and body fat percentage
- Longitudinal
- Linear mixed-effects model adjusted for age, breastfeeding status, daily total calorie intake and body fat percentage
Main finding
As reported in the abstract
Associations of PFAS with trajectories of diabetes indicators
- Increased 2-(N-methyl-perfluorooctane sulfonamido) acetate associated with faster increase in fasting glucose
- P = 0.003
- Increased perfluorononanoate (PFNA) associated with faster increase in fasting insulin
- P = 0.04
- Increased n-PFOA associated with faster increase in fasting insulin
- P = 0.02
- Increased PFNA associated with faster decrease in acute insulin response to glucose
- P = 0.04
- Increased n-PFOA associated with faster decrease in acute insulin response to glucose
- P = 0.02
Observational data: associations, not effects.
Original publication
Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus. Diabetes Care. Published 28 January 2025. doi:10.
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