Gestational diabetes & diabetes in pregnancy
Automated insulin delivery during the first 6 months postpartum (AiDAPT): a prespecified extension study
Primary result · TIRResult — go to the resultAdjusted treatment difference 15 % 95% CI 7–22Authors' conclusion
Participants in the HCL group maintained 70% TIR during the first 6 months postpartum, supporting continued use of HCL rather than standard insulin therapy for people with diabetes once they have given birth.
Study context
- Population
- Women with T1D followed up for 6 months postpartum after the AiDAPT pregnancy trial, nine UK sites; mean age 31 years, early pregnancy HbA1c 59.4 mmol/molof 124 AiDAPT participants
- Participants
- 57 women
- Comparison
- Hybrid closed loop (HCL) vs standard insulin therapy with CGM
- Primary endpoint
- Between-group difference in % TIR (3.9-10.0 mmol/L), months 0 up to 3, months 3 to 6, and over 6 months postpartum
- Follow-up
- 6 months postpartum
Methodological detailsmulticentre, stratified by clinical site
- Multicentre
- Stratified by clinical site
Primary result
TIR
Adjusted treatment difference
15 %
95% CI 7–22
By group
HCLvs Standard care
adjusted treatment difference 15 % (95% CI 7–22)
As reported in the abstract
Further findings
| Outcome | Difference (%) (95% CI) | |
|---|---|---|
| Hyperglycaemia (>10.0 mmol/L) · 6 months postpartum | −14 (−23% to −6%) | |
| −30−20−10010Difference, % (linear scale) |
| Outcome | Difference (mmol/L) (CI) | |
|---|---|---|
| Mean CGM glucose · 6 months postpartum | −1.3 (−2.3 to −0.3) | |
| −3−2−101Difference, mmol/L (linear scale) |
Treatment effect by postpartum period · 0 up to 3 months vs 3 to 6 months
- No treatment effect changes depending on postpartum period
Safety
Hypoglycaemia · 6 months postpartum
- Hypoglycaemia rates were low, with no between-group differences
- 2.4% vs 2.6%
- No unanticipated safety problems
Original publication
Automated insulin delivery during the first 6 months postpartum (AiDAPT): a prespecified extension study. Lancet Diabetes Endocrinol. Published 27 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →