Gestational diabetes & diabetes in pregnancy
Gestational diabetes: One size does not fit all—an observational study of maternal and neonatal outcomes by maternal glucose profile
Authors' conclusion
Elevated fasting plasma glucose, either alone or combined with post-load glucose elevation is associated with worse outcomes than isolated post-load glucose elevation, possibly due to higher degrees of insulin resistance. Future work is needed to better understand these differences, and explore whether tailored treatment of GDM can improve neonatal outcomes.
Study context
- Population
- All pregnancies with GDM screening, Oct 2008–Dec 2018, resulting in live singleton birth, Alberta, Canada; independent cohort of 1451 women for insulin sensitivity/beta-cell function
- Participants
- 436,773 pregnancies
- Exposure
- Seven maternal glucose profiles at GDM screening
- Outcome
- LGA and NICU admission rates
Methodological detailsindependent well-phenotyped cohort for insulin sensitivity and beta-cell function
- Independent well-phenotyped cohort for insulin sensitivity and beta-cell function
Main finding
As reported in the abstract
| Group | Value | Neonatal intensive care unit (NICU) admissions |
|---|---|---|
| Combined | 20.9% | 14.7% |
Combined
Value20.9%
Neonatal intensive care unit (NICU) admissions14.7%
Observational data: associations, not effects.
Further findings
Insulin sensitivity (Matsuda index, HOMA-IR) and beta-cell function (ISSI-2, insulinogenic index/HOMA-IR)
- Elevated FPG, isolated or combined, had lower insulin sensitivity
- Combined profile had the lowest insulin sensitivity and beta-cell function
- Independent cohort of 1451 women
Original publication
Gestational diabetes: One size does not fit all—an observational study of maternal and neonatal outcomes by maternal glucose profile. Diabet Med. Published 31 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →