Gestational diabetes & diabetes in pregnancy
Gestational diabetes and maternal morbidity in multifetal pregnancies: independent contributions of gestational diabetes mellitus (GDM) and plurality
Authors' conclusion
Both GDM and multifetal gestation were independently associated with maternal morbidity. Multifetal gestation showed stronger associations with hypertensive outcomes, without evidence of interaction between the two exposures.
Study context
- Population
- Pregnancies at six university-affiliated medical centers, 2010–2024
- Participants
- 134,517 pregnancies
- Exposure
- GDM and multifetal gestation, alone and combined, vs singleton pregnancy without GDM
- Outcome
- Hypertensive disorders of pregnancy (HDP)
Methodological detailsnational, multicentre, six university-affiliated medical centers, OMOP Common Data Model, multivariable Firth logistic regression
- National
- Multicentre
- Six university-affiliated medical centers
- OMOP Common Data Model
- Multivariable Firth logistic regression
Main finding
As reported in the abstract
HDP
Adjusted odds ratio (95% CI)
GDMvs No GDM
1.7(1.6–1.8)
- Multifetal gestation vs Singleton
- aOR 2.2-2.5
- No statistically significant interaction between GDM and multifetal gestation for hypertensive disorders of pregnancy (HDP)
- q = 0.088
Observational data: associations, not effects.
Further findings
| Outcome | aOR |
|---|---|
| HDP with multifetal gestation | 2.2-2.5 |
| Severe preeclampsia with multifetal gestation | 3.6 |
ICP, multifetal with GDM
- ICP was most frequent in multifetal pregnancies with GDM
Interaction between GDM and multifetal gestation for HDP
- No statistically significant interaction between GDM and multifetal gestation for HDP
- q = 0.088
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Gestational diabetes and maternal morbidity in multifetal pregnancies: independent contributions of GDM and plurality. Diabetes Res Clin Pract. Published 22 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →