Gestational diabetes & diabetes in pregnancy
Enhanced glucose processing in gestational diabetes diagnosis: Effects on health equity and clinical outcomes
Authors' conclusion
An OGTT with enhanced glucose processing would support more accurate, equitable diagnosis of gestational diabetes, but with increased diagnosis rates.
Study context
- Population
- Pregnant women with ≥1 GDM risk factor undergoing 75 g antenatal oral glucose tolerance test (OGTT) (NICE criteria), 9 UK centres (OPHELIA); mean age 31.5 years, BMI 33.0 kg/m², 82.5% white
- Participants
- 1,308 women
- Exposure
- Enhanced vs standard pre-analytical glucose processing during OGTT
- Outcome
- Glucose levels and GDM diagnosis
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Glucose levels higher with enhanced vs standard processing
- ≈0.6 mmol/L
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics and outcomes of women with GDM on enhanced but not standard processing (n = 165) vs GDM on standard processingGDM on enhanced only vs GDM on standard · 31.9 vs. 33.2 years; younger with enhanced only | P = 0.035 |
| Characteristics and outcomes of women with GDM on enhanced but not standard processing (n = 165) vs GDM on standard processingGDM on enhanced only vs GDM on standard · 36.5 vs. 33.9 kg/m² | P = 0.003 |
| Characteristics and outcomes of women with GDM on enhanced but not standard processing (n = 165) vs GDM on standard processingGDM on enhanced only vs GDM on standard · different ethnic distribution | P = 0.025 |
| Characteristics and outcomes of women with GDM on enhanced but not standard processing (n = 165) vs GDM on standard processingGDM on enhanced only vs GDM on standard · 37.0% vs. 22.3% | P = 0.006 |
HbA1c as predictor of GDM diagnosis
- HbA1c AUC (not a suitable alternative)
- 0.74; 95% CI 0.68-0.79
Original publication
Enhanced glucose processing in gestational diabetes diagnosis: Effects on health equity and clinical outcomes. Diabet Med. Published 17 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →