Gestational diabetes & diabetes in pregnancy
Oxidative stress, senescence and mRNA decay in peripheral blood mononuclear cells of women with gestational diabetes mellitus ‐link to increased cardiovascular disease risk
Authors' conclusion
Markers of vascular oxidative stress and senescence are increased and correlate with indices of glucose and lipid metabolism early in pregnancy in women developing GDM. Cellular markers reflecting attenuated defence against oxidative stress and senescence decrease throughout pregnancy and at 5-year follow-up and correlate with aortic stiffness in women with previous GDM.
Study context
- Population
- Pregnant women from the STORK study, assessed during pregnancy and at 5-year follow-up
- Participants
- 31 vs 253
- Comparison
- Women with gestational diabetes mellitus (GDM) vs healthy women
- GDMn = 31
- Healthyn = 253reference
- Outcome
- Oxidative stress and senescence markers
Methodological detailsfrom the STORK study, 5-year follow-up
- From the STORK study
- 5-year follow-up
Main finding
As reported in the abstract
- Plasma advanced oxidation protein products (AOPP) and β-galactosidase increased early in pregnancy in women later developing GDM, associated with indices of glucose metabolism and TG/HDL-C
- RNA levels of transcripts involved in telomere maintenance and antioxidant responses decreased in GDM during pregnancy and at follow-up
- DCP2 and XRN1 expression positively associated with β-cell function at all timepoints and with pulse wave velocity at 5-year follow-up in women with previous GDM
Original publication
Oxidative stress, senescence and mRNA decay in peripheral blood mononuclear cells of women with gestational diabetes mellitus ‐link to increased cardiovascular disease risk. Diabetes Obes Metab. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →