Gestational diabetes & diabetes in pregnancy
Pre‒pregnancy body mass index and Gestational Diabetes as key determinants of long‒term metabolic risk: insights from a nutritional intervention during pregnancy
Authors' conclusion
GDM diagnosed using IADPSG criteria identifies women at increased long-term risk of MetS confirming its cardiovascular relevance. Early MedDiet intervention (8-12 GW) during pregnancy provides sustained metabolic benefits while pre-pregnancy BMI and GDM emerge as key modifiable determinants. Lifestyle cut-off points relevant to postpartum MetS prevention were identified.
Study context
- Population
- Women randomised during pregnancy, assessed six years postpartum
- Participants
- 1,715 women
- Comparison
- MedDiet-based nutritional intervention during pregnancy vs control
- Primary endpoint
- Prevalence of metabolic syndrome (MetS)
- Follow-up
- Six years postpartum
Methodological detailssix years postpartum
- Six years postpartum
Primary result
As reported in the abstract
P = 0.034
Further findings
Metabolic parameters · six years postpartum
- Improved metabolic parameters with intervention
Modifiable risk factors for metabolic syndrome (MetS) (multivariate models) · six years postpartum
- Elevated pre-pregnancy BMI, OR [CI]
- 7.912 [5.411-11.57]
- Gestational Diabetes Mellitus (GDM) (IADPSG criteria), OR [CI]
- 2.958 [2.056-4.256]
- Strongest MetS modifiable risk factors
Postpartum lifestyle cut-offs (ROC analysis) · six years postpartum
- MedDiet ≥7.5 points and physical activity ≥307.5 MET·min/week reduced MetS risk by up to
- 62 %
- Adjusted for confounders
Original publication
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