Gestational diabetes & diabetes in pregnancy
Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta‐analysis of observational studies
Pooled result · Associations of modifiable risk factors with perinatal outcomesResult — go to the resultOdds ratio 2.39 95% CI 1.74–3.29Authors' conclusion
Based on observational evidence, increasing access to preconception care could be beneficial to optimize maternal nutrition and weight-related outcomes, and addressing obesity and GWG has the potential to improve maternal and neonatal outcomes in pregnancies affected by T2D.
Study context
- Population
- Women with pregestational T2D and their children; observational studies from six databases (September 2023)58 studies
- Comparison
- Modifiable preconception, pregnancy and postpartum risk factors
- Outcome
- Associations of modifiable risk factors with perinatal outcomes
Methodological detailsrandom effects meta-analysis, narrative synthesis, Screening, data extraction and quality assessments by two reviewers
- Random effects meta-analysis
- Narrative synthesis
- Screening, data extraction and quality assessments by two reviewers
Pooled result
As reported in the abstract
Odds ratio
2.39
95% CI 1.74–3.29
Excessive GWG
OR 2.39 (95% CI 1.74–3.29)
Further pooled results
Narrative synthesis
- Preconception care associated with increased use of folic acid and vitamin D, and reduced gestational weight gain (GWG)
- Higher BMI associated with multiple suboptimal pregnancy, birth and neonatal outcomes
- Excessive GWG associated with increased insulin requirements and increased likelihood of neonatal hypoglycaemia
- Metformin/oral hypoglycaemic medications associated with reduced GWG and fewer caesarean deliveries
- Mixed or no evidence of association for other reported exposures and outcomes
Original publication
Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta‐analysis of observational studies. Diabet Med. Published 7 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →