Gestational diabetes & diabetes in pregnancy
Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia
Authors' conclusion
Aboriginal women in the NT with GDM or pre-existing diabetes during pregnancy are at high risk of developing CKD and ESKD. Pregnancy presents an important opportunity to identify kidney disease risk. Strategies to prevent kidney disease and address the social determinants of health are needed.
Study context
- Population
- Aboriginal women who gave birth between 2000 and 2016 in the Northern Territory, Australia; mean age 23.1 (SD 6.1) years
- Participants
- 10,508 women
- Exposure
- Gestational diabetes mellitus (GDM) or pre-existing diabetes in pregnancy vs no diabetes during pregnancy
- GDMn = 731
- Pre-existing diabetesn = 239
- Outcome
- Any stage of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) (ICD-10 coding, Northern Territory (NT) Hospital Inpatient Activity dataset 2000–2018)
- Follow-up
- Median 12.1 years
Methodological detailslongitudinal, data-linkage
- Longitudinal
- Data-linkage
Main finding
As reported in the abstract
CKD
Each group vs no diabetesAdjusted hazard ratio (95% CI)
GDM
5.2(3.9–7.1)
Pre-existing diabetes
10.9(7.7–15.4)
Observational data: associations, not effects.
Further findings
| Outcome | GDM | Pre-existing diabetes | No diabetes | aHR (95% CI) | |
|---|---|---|---|---|---|
| ESKDGDMvs No diabetes | 2.4% | 9.9% | 0.4% | 10.8 (5.6–20.8) | |
| ESKDPre-existing diabetesvs No diabetes | 28.0 (13.4–58.6) | ||||
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia. Diabetologia. Published 18 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →