Gestational diabetes & diabetes in pregnancy
Postpartum Body Weight and Cardiometabolic Biomarker Trajectories in Women With Gestational Diabetes: A Population‐Based Matched Cohort Study
Authors' conclusion
Differences in biomarker trajectories in the early postpartum present an opportunity for early risk stratification and targeted prevention among women with previous GDM.
Study context
- Population
- Women who gave birth between 2001 and 2021, electronic primary care records linked to hospital episode recordsmatched cohort
- Participants
- 43,572 vs 174,288
- Exposure
- Women with GDM vs women without GDM
- GDMn = 43,572
- Non-GDMn = 174,288reference
- Outcome
- Postpartum trajectories in body weight and cardiometabolic biomarkers
- Follow-up
- 15-year follow-up
Methodological detailsmatched 1:4 on age at delivery and delivery date (±3 months), mixed-effects multivariate linear models
- Matched 1:4 on age at delivery and delivery date (±3 months)
- Mixed-effects multivariate linear models
Main finding
As reported in the abstract
Each group vs Non-GDMDifference (weight), kg (95% CI)
GDM
5.5(5.3–5.7)
Each group vs Non-GDMDifference (HbA1c), mmol/mol (95% CI)
GDM
4.4(4.3–4.5)
Each group vs Non-GDMEstimate (95% CI)
GDM
difference (systolic blood pressure) 2.6 mmHg(2.4–2.7)
GDM
difference (diastolic blood pressure) 1.7 mmHg(1.6–1.8)
Each group vs Non-GDMDifference (LDL-C) (95% CI)
GDM
0.08(0.06–0.10)
Observational data: associations, not effects.
Further findings
Increase in HbA1c during follow-up · 15-year follow-up
Rate of increase in biomarkers during follow-up · 15-year follow-up
- Biomarkers increased at a slower rate among women with GDM, except for HbA1c
Moderation by progression to T2D
- Future progression to T2D moderated biomarker trajectories
Original publication
Postpartum Body Weight and Cardiometabolic Biomarker Trajectories in Women With Gestational Diabetes: A Population‐Based Matched Cohort Study. Diabetes Obes Metab. Published 22 June 2026. doi:10.
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