Gestational diabetes & diabetes in pregnancy

Hair Mercury Levels, Serum n-3 Fatty Acids, and Pregnancy Glucose Outcomes Among Women From a Fertility Center

J Clin Endocrinol MetabPublished Prospective cohort study

Main finding · GlucoseResult — go to the resultβ 0.09 95% CI 0.002–0.19

Authors' conclusion

Higher prepregnancy Hg exposure was associated with increased IGT odds, potentially modified by BMI and n-3 PUFA status.

Study context

Population
Women from a fertility center (Environment and Reproductive Health Study) with prepregnancy hair Hg and mid- to late-pregnancy glucose levels; 182 with prepregnancy serum eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)182 with serum EPA/DHA
Participants
430 women
Exposure
Prepregnancy hair Hg exposure
Outcome
Pregnancy glucose levels and impaired glucose tolerance (IGT)
Follow-up
Mid- to late-pregnancy

Main finding

Glucose

β

0.09

95% CI 0.002–0.19

As reported in the abstract

Increased odds of impaired glucose tolerance (IGT), Q4 vs Q1
2.05-fold

Observational data: associations, not effects.

Further findings

Stratified by EPA + DHA and body mass inde (BMI)

Similar associations among women with lower circulating EPA + DHA
Stronger associations among women with prepregnancy BMI ≥25 kg/m²

Original publication

Hair Mercury Levels, Serum n-3 Fatty Acids, and Pregnancy Glucose Outcomes Among Women From a Fertility Center. J Clin Endocrinol Metab. Published 29 October 2025. doi:10.1210/clinem/dgaf594

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