Gestational diabetes & diabetes in pregnancy
Hair Mercury Levels, Serum n-3 Fatty Acids, and Pregnancy Glucose Outcomes Among Women From a Fertility Center
Main finding · GlucoseResult — go to the resultβ 0.09 95% CI 0.002–0.19Authors' conclusion
Higher prepregnancy Hg exposure was associated with increased IGT odds, potentially modified by BMI and n-3 PUFA status.
Study context
- Population
- Women from a fertility center (Environment and Reproductive Health Study) with prepregnancy hair Hg and mid- to late-pregnancy glucose levels; 182 with prepregnancy serum eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)182 with serum EPA/DHA
- Participants
- 430 women
- Exposure
- Prepregnancy hair Hg exposure
- Outcome
- Pregnancy glucose levels and impaired glucose tolerance (IGT)
- Follow-up
- Mid- to late-pregnancy
Main finding
Glucose
β
0.09
95% CI 0.002–0.19
As reported in the abstract
- Increased odds of impaired glucose tolerance (IGT), Q4 vs Q1
- 2.05-fold
Observational data: associations, not effects.
Further findings
Stratified by EPA + DHA and body mass inde (BMI)
- Similar associations among women with lower circulating EPA + DHA
- Stronger associations among women with prepregnancy BMI ≥25 kg/m²
Original publication
Hair Mercury Levels, Serum n-3 Fatty Acids, and Pregnancy Glucose Outcomes Among Women From a Fertility Center. J Clin Endocrinol Metab. Published 29 October 2025. doi:10. 1210/ clinem/ dgaf594
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