Gestational diabetes & diabetes in pregnancy
Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits
Main finding · Genetic loci associated with GDM susceptibilityResult — go to the resultOdds ratio 1.57 95% CI 1.45–1.70Authors' conclusion
Our findings provide new insights into the genetic basis of GDM and glycaemic traits during pregnancy in an East Asian population and highlight the potential role of inflammatory pathways in the aetiology of GDM and variations in glycaemic levels.
Study context
- Population
- Chinese pregnant women with non-invasive prenatal test (NIPT) sequencing data and glycaemic and biochemical measurements over 2 years, Shenzhen Baoan Women's and Children's Hospital, China
- Participants
- 30,699 women
- Comparison
- Gestational diabetes mellitus (GDM) vs control participants
- GDMn = 3,317
- Controln = 19,565reference
- Outcome
- Genetic loci associated with GDM and glycaemic traits (FPG; 0 h, 1 h, 2 h OGTT glucose)
Methodological detailssingle-centre, one-sample Mendelian randomisation, replication in two independent cohorts
- Single-centre
- One-sample Mendelian randomisation
- Replication in two independent cohorts
Main finding
Genetic loci associated with GDM susceptibility
Odds ratio
1.57
95% CI 1.45–1.70
P = 4.42×10-29
GDMvs control participants
OR 1.57 (95% CI 1.45–1.70); P = 4.42×10-29
As reported in the abstract
- Genetic loci significantly associated with GDM susceptibility
- 4
Further findings
Genetic loci associated with the four glycaemic traits
- Loci significantly associated
- 31
- Novel loci
- 14
Replication rates
- GDM
- 4 out of 4
- FPG
- 6 out of 9
- 0 h OGTT glucose
- 10 out of 11
- 1 h OGTT glucose
- 5 out of 7
- 2 h OGTT glucose
- 4 out of 4
Mendelian randomisation of biochemical measurements
- Genetically regulated higher lymphocytes percentage and lower white blood cell count, neutrophil percentage and absolute neutrophil count associated with elevated glucose levels and increased GDM risk
Original publication
Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits. Diabetologia. Published 19 February 2024. doi:10.
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