Plasma concentration of gastrointestinal hormones and subjective appetite ratings after diet or bariatric surgery: 1-year results from the DISGAP study
Authors' conclusion
Weight change at 1Y follow up after SG and RYGB is followed by a GI hormone profile favoring a lower drive to eat and increased satiety. The opposite is seen 1Y after WL induced by dietary restriction alone.
Study context
- Population
- Patients scheduled for Sleeve Gastrectomy (SG) or RYGB, and controls; 10-week VLED then 9-month maintenance phasecompleters of all three follow-ups analysed
- Participants
- 19 / 19 / 16
- Exposure
- SG or RYGB after VLED vs VLED alone
- SGn = 19
- RYGBn = 19
- Controlsn = 16reference
- Outcome
- Changes in gastrointestinal (GI) hormones involved in appetite regulation (ghrelin, GLP-1, PYY, CCK) and subjective appetite feelings
- Follow-up
- 1-year follow-up
Main finding
As reported in the abstract
1Y
- Postprandial GLP-1 increased over time post bariatric surgery; unchanged and lower in controls
- Postprandial PYY increased in all groups, greatest post-RYGB
- Basal ghrelin decreased post-SG; small increase after RYGB and marked increase after diet; controls had greatest basal and postprandial ghrelin at 1Y
- Basal and postprandial CCK reduced in controls at 1Y; no changes post-bariatric surgery
- Small changes in subjective appetite ratings over time
Observational data: associations, not effects.
Further findings
- Initial changes in body weight/composition comparable across groups
- SG (n = 11) and RYGB (n = 12) continued to lose weight from W11 to 1Y; controls (n = 12) regained weight
Original publication
Plasma concentration of gastrointestinal hormones and subjective appetite ratings after diet or bariatric surgery: 1-year results from the DISGAP study. Int J Obes (Lond). Published 21 November 2024. doi:10.
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