Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study
Authors' conclusion
Overall, we show that BS interventions are associated with higher glycemic variability. Moreover, depending on the type of gastrointestinal anatomical reconstruction, BS yields procedure specific glycemic variability patterns. This might be due to faster glucose absorption, impaired amino acid absorption, and/or altered entero-pancreatic hormone profiles, including GLP-1 and insulin secretion.
Study context
- Population
- Individuals after metabolic and bariatric surgery (BS) and non-operated matched controls; 14 days of intermittently scanned continuous glucose monitoring (isCGM)
- Participants
- 8 / 7 / 8 / 7 / 8
- Exposure
- Four BS procedures vs non-operated matched controls
- C-RYGBn = 8
- M-RYGBn = 7
- SADI-Sn = 8
- Biliopancreatic diversion with duodenal switch (BPD-DS)n = 7
- Controlsn = 8reference
- Outcome
- Mean absolute glucose change (MAG change) in operated vs non-operated individuals
Methodological detailsmatched non-operated controls, Automated tool Gluc4all developed, validated and released for CGM data analysis
- Matched non-operated controls
- Automated tool Gluc4all developed, validated and released for CGM data analysis
Main finding
As reported in the abstract
MAG change
Fold higher
- C-RYGB
- 2.0
- M-RYGB
- 2.0
- SADI-S
- 1.6
- BPD-DS
- 1.6
Observational data: associations, not effects.
Further findings
Mixed-meal test hormone profiles (surgical groups)
- isCGM findings matched postprandial glucose, GIP, GLP-1 and insulin profiles in the meal test
Original publication
Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study. Int J Obes (Lond). Published 9 August 2025. doi:10.
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