Obesity

Dietary Macronutrient Composition and Protein Concentration for Weight Loss Maintenance

Obesity (Silver Spring)Published Prospective cohort study

Authors' conclusion

Maintaining dietary proportional energy from protein, particularly by limiting discretionary food consumption, was associated with reduced energy intake and improved WLM.

Study context

Population
Adults who achieved initial weight loss (≥ 5%); 69.8% women; mean age 45 ± 12 years
Participants
1,518 adults
Outcome
Changes in body weight, fat mass index (FMI), waist-to-height ratio (WHtR) and hip-to-height ratio (HHtR)
Follow-up
12 months
Methodological details12-month follow-up of the Navigating to a Healthy Weight trial, nutritional geometry approach
  • 12-month follow-up of the Navigating to a Healthy Weight trial
  • Nutritional geometry approach

Main finding

As reported in the abstract

Mean macronutrient composition: protein

20.6%

Mean macronutrient composition: fat

33.8%

Mean macronutrient composition: carbohydrate

43.1%

Protein energy % vs energy intake, β

−0.33 (−0.39, −0.27) (95% CI)

Observational data: associations, not effects.

Further findings

Discretionary food, not other food sources, increased energy intake by reducing proportional energy from protein

Original publication

Dietary Macronutrient Composition and Protein Concentration for Weight Loss Maintenance. Obesity (Silver Spring). Published 7 August 2025. doi:10.1002/oby.24370

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